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摘要：用氯化亚铁、氯化铁、氢氧化钠、吐温-80、氨水、聚乙二醇，在微乳液中反应生成纳米四氧化三铁，最佳的反应条件是：FeCl3·6H2O与FeCl2·4H2O的摩尔比为3:2，反应时间为30min，反应温度为55℃，乳化剂为1g，将得出的结论做成最终产物，然后测试其纳米粒子的粒径大小；在将做出的纳米粒子与壳聚糖、叶酸、聚乙二醇反应，来修饰纳米粒子，最佳的条件是：纳米粒子：壳聚糖：叶酸为1:3:3，反应时间为180min，反应温度为45℃，与壳聚糖静电自组装合成了动力学药物载体纳米磁性壳聚糖复合颗粒(PHPP—Fes04)／CS用油酸包覆的复合颗粒Fe304／OA吸附PHPP，然后采用微乳液和溶胶磁靶阳药物纳米制剂的合成及性能研究。 用红外光谱测试其特征与性能，红外光谱证实了壳聚糖与叶酸是以离子键结合的。61956
毕业论文关键词：壳聚糖；叶酸；纳米粒子；聚乙二醇；靶向性；阿胶；实验
Abstract: Ferrous chloride, ferric chloride, sodium hydroxide,
Using tween- 80, ammonia, polyethylene glycol, The reaction of iron oxide was produced in the micro-emulsion.The optimal reaction conditions were that the proportion of FeCl3 · 6H2O :FeCl2 · 4H2O was 3: 2, reaction time was 30 min, the reaction temperature was 55 ℃, the emulsifier is 1g and the final product were made on the conditions, and particle size nanoparticles were characterized.In the chitosan nanoparticles, folic acid and polyethylene glycol reaction the modified nanoparticles were made.The best conditions were that nanoparticles: chitosan: folic acid was 1: 3: 3, the reaction time was 180min, the reaction temperature was 45 ℃, the chitosan electrostatic self-assembly kinetics of the drug carrier was synthesized magnetic chitosan composite particles (PHPP-Fes04) / CS composite particles coated with oleic acid Fe304 / OA adsorption PHPP, then micro-emulsion synthesis and properties of sol and magnetic target male drug nanoparticles formulation. Were Characterized by infrared spectroscopy and properties.On IR spectra, the Infrared characteristic peak of the chitosan and folic acid are shown
Keywords: chitosan; folic acid; nanoparticles; polyethylene glycol; targeting; gelatin;
1绪论.6
1.1 靶向给药系统6-8
1.1.1靶向制剂的分类..6-8
1.1.2 靶向给药载体的选择8
1.2 壳聚糖 8-12
1.2.1.1 壳聚糖的物理性质.8-9
1.2.1.2 壳聚糖的化学性质9
1.2.2 壳聚糖作为载体材料的优势.9
1.2.2.1 良好的生物可降解性和生物相容性.9
1.2.2.2 抗肿瘤作用..10
1.2.3 壳聚糖纳米粒载体的优势..10
1.2.3.1 延缓控制药物释放..10
1.2.3.2 促进药物吸收10
1.2.3.3 降低药物毒副作用..10-11
1.2.3.4 增加药物稳定性.11
1.2.4 壳聚糖微粒/纳米粒的制备方法11
1.2.4.1 离子交联法..11
1.2.4.2 共价交联法..11
1.2.4.3 凝聚法12
1.2.4.4 乳胶聚结法..12
1.2.4.5 方法总结.12
1.3 叶酸与叶酸受体12-14
1.3.1 叶酸的基本特性.12
1.3.2 叶酸受体的基本特性13
1.3.3 叶酸-聚合物靶向系统..13
1.3.3.1 叶酸-聚乙二醇载药体系14
1.3.3.2 叶酸-两亲性嵌段共聚物载药体系.14
1.3.3.3 叶酸-树枝状聚合物载药体系..14
1.4 阿胶.15-17
1.4.1 阿胶的定义及性质.15