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摘要近年来随着现代医学技术的迅速发展，智能响应型纳米颗粒药物在药物释放控制体系中已经受到广泛关注。它对于控制药物释放速度、减少药物的副作用等有重要意义。针对人体不同组织结构微环境的pH微小变化（正常组织细胞的pH 值接近中性，而病变组织细胞的pH值呈现弱酸性，在5.5～6.9之间），一类基于pH响应的智能靶向药物逐步成为关注的热点。本论文以聚酰胺一胺型树状大分子的药物载体为pH响应型目标靶向药物载体，以乙二胺为核，丙烯酸甲酯为外壳，采用发散法通过Michael加成和酰胺化重复反应合成不同代数的聚酰胺一胺型树状大分子PAMAM。并使用红外吸收光谱及核磁共振对PAMAM 的结构进行了表征；以FeCl3•6H2O为铁源，与1,6-NH2-(CH2)6-NH2在200℃下，用乙二醇作溶剂，采用简单的一步法合成表面氨基化的磁性纳米颗粒，用红外吸收光谱和XRD对其结构进行了表征；最后将PAMAM与磁性纳米颗粒进行复合，得到载药前体，并对复合产物的结构进行了红外表征。5932
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关键词 树状大分子 聚酰胺-胺 磁性纳米颗粒 pH响应性
毕业设计说明书（论文）外文摘要
Title Design and preparation of pH response-oriented and magnetic dendrimers
Abstract
With the rapid development of modern medical technology in recent years, intelligent responsive nanoparticle drug in drug release control system has attracted widespread attention. It is important for controlling the drug release rapid rate, reducing the side effects of drugs. Human body’s different organizations have different pH value (The normal tissue cells’ value is neutral. Diseased tissue cells’ pH value is weakly acidic,it is from 5.5 to 6.9). A kind of intelligent targeted drugs based on pH-responsive carrier has gradually become hot.By the research of polyamide-amine (PAMAM) dendritic drug carriers, we use ethylenediamine as core and methyl acryl ate as case to synthesize PAMAM. Divergent method is repeating Michael addition and amide reaction. Then using the infrared absorption spectrum and nuclear magnetic resonance (NMR) to characterize the structures of different generation PAMAM；we use FeCl3•6H2O as iron source, 1,6-NH2-(CH2)6-NH2 and ethylene glycol are added to it. Using this method can we get amine megnetic nanoparticles. Then using the infrared absorption spectrum and X-ray powder diffraction (XRD) to characterize the structures.At last, the amine megnetic nanoparticles and PAMAM will be composited. The product can be characterized by nfrared absorption spectrum and X-ray powder diffraction (XRD).
Keywords dendrimers polyamide-amine magnetic nanoparticles pH-responsive
目录
1 绪论 1
1.1 研究背景 1
1.2 国内外研究现状 1
1.3 磁性纳米材料 2
1.4 树状大分子 3
1.5 聚酰胺-胺（PAMAM ）树状分子 4
1.6 本论文的研究的目的和内容 7
2 聚酰胺-胺（PAMAM）合成方法探究 8
2.1 实验试剂和仪器 8
2.2 产品制备 9
2.3 结果与讨论 11
2.4 本章小结 15
3 氨基化Fe3O4的制备 15
3.1 实验试剂和仪器 15
3.2 产品制备 16
3.3 结果分析与讨论 17
3.4 本章小结 18
4 PAMAM- Fe3O4复合物的制备 19
4.1 实验试剂和仪器 19
4.2 产品制备 19